United faced Wolves last year in the third round of the Carling Cup, with the tie being decided by a Danny Welbeck second half goal.
Mick McCarthy returns to Old Trafford for the first time since last Wolves lost 2-0 last December. After fielding a weakened side against Man United during that game, Wolves were fined £250,000.
Sir Alex Ferguson is expected to field some of the younger players, with Federico Macheda, Darron Gibson, Bebe and Chris Smalling all expected to play a part. Michael Owen has reportedly recovered from a hamstring injury, which could mean that he may start up front.
Antonio Valencia, Wayne Rooney, Owen Hargreaves, Ryan Giggs and Jonny Evans will all be unavailable for the clash.
Wolves will be without Ronald Zubar, Michael Knightly and Jody Cradock, who are all injured. They will also be without the suspended Karl Henry.
