This weekend the oldest cup competition returns with Manchester United playing yet another Premier League side.
Here is the match preview, the match will also be live here- teams, yellow cards, red cards, important details, goals, subs etc...
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Manchester United
Squad: Van der Sar, Brown, Vidic, Ferdinand, Evra, Ronaldo, Carrick, Fletcher, Hargreaves, Nani, Rooney, Tevez, Scholes, Giggs, O'Shea, Saha, Kuszczak, Anderson, Park, Simpson, Pique.
Injuries: United have no new injuries, Neville, Foster and Silvestre are still out with long term injuries.
Form: WWWDW
Manchester United 1-0 Lyon
Fulham 3-0 Manchester United
Newcastle 1-5 Manchester United
Lyon 1-1 Manchester United
Manchester United 4-0 Arsenal
Manager: "I have a difficult choice to make. That seems to be the norm at the moment but something I relish.
"I am happy about the situation as without this squad we would not be where we are.
"We have a home draw and that is all you can ask for. Hopefully we will come through okay."

Portsmouth
Squad: James, Ashdown, Johnson, Distin, Campbell, Hreidarsson, Lauren, Aubey, Diop, Diarra, Muntari, Utaka, Davis, Mendes, Hughes, Kanu, Baros
Injuries: Mendes returns from injury. Primus and Nugent are out.
Form: LWWWD
Everton 3-1 Portsmouth
Portsmouth 1-0 Sunderland
Preston 0-1 Portsmouth
Bolton 0-1 Portsmouth
Portsmouth 1-1 Chelsea
Manager:
"If we are ready physically and mentally and we keep our shape, we have enough quality to battle against United.
"I am not going there to avoid defeat. I am going there to win.
"If you go there to avoid defeat, mentally, you are not ready and there is no point in going there."
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Predictions:
BBC's Mark Lawrenson's Prediction: Manchester United 2-0 Portsmouth
My Prediction: Manchester United 2-1 Portsmouth