The League One side yesterday beat an under strength Blackpool side 2-0 at St Mary's Stadium.
The last time the two sides met was in the third round of the FA Cup back 2009, which United won 3-0 with goals from Danny Welbeck, Luis Nani (penalty) and Darron Gibson. Before that United and Southampton faced each other three times in the 2004/05 season, twice in the league and once in the FA Cup. United won all three games.
Head-to-head the two clubs have played each other a total of 109 times in all competitions. Man United have won 56 times, Southampton 25 times and there have been 28 draws. 14 of the 109 games have been played in the FA Cup, United have won eight times, lost only once and there have been five draws.
